Biomaterials exist at the intersection of biology and engineering. This course explores natural structural materials in the human body, their properties and microstructure, and their synthetic and semi-synthetic replacements. Bones, joints, teeth, tendons, and ligaments are used as examples, with their metal, plastic, and ceramic replacements. Topics covered include mechanical properties, corrosion, toxicity, and biocompatibility. Case studies of design lead to consideration of regulatory approval requirements and legal liability issues.